在451号位点引入了C到T的无义突变([c.451C>T (CGA>TGA)]),这预测会导致密码子151由arginine变为终止密码子(p.R151X)。在形成嵌合鼠之前,ES细胞中去除了loxP位点的诺卡因选择标记 cassette。(来源:J:261869)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6J
Targeted
单点
--
1
4
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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