通过CRISPR/cas9介导的重组,产生了一个6个碱基对的缺失,涉及到了起始密码子所在的exon 1。免疫印迹分析显示,纯合子小鼠中没有蛋白质表达。(来源:J:259133)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
CBA x C57BL/6
Endonuclease-mediated
基因内删除
--
1
5
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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