在exon 1上游4KB位置插入了loxP位点,接着是带有FRT标签的新基因座和另一个loxP位点,位于exon 6下游2KB。通过Cre介导的重组,这些元件在生殖细胞中去除了exons 1-6,随后的 Western blot 对白细胞匀浆的检测确认了没有蛋白质表达。(来源:J:261549)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Targeted
插入,基因内删除
--
1
1
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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