这个来自TCPR0724项目的等位基因是在phenogenomics中心通过向细胞注射Cas9 mRNA和四条带有CAACTACGTACTTGAGAAGT和TATAGTGCCAGATCATACAG的指导RNA,这些RNA的 spacer序列分别为5'侧的CTACGTACTTGAGAAGT和3'侧的TTGGATCTTGCTGTGTTCTC和CTCTATAAGCACCTCGGAAA,针对ENSMUSE00000289168和ENSMUSE00000117231基因的相应位置。这导致了chr13染色体上一个1667bp的删除,范围从27712921到27714587,以及chr13上一个3bp的删除,位置在27714679到27714677。(GRCm38参考序列,J:237616)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NCrl
Endonuclease-mediated
基因内删除
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1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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