这个来自TCPR1019项目的等位基因是在表观基因组学中心通过电穿孔,将Cas9核糖核酸蛋白复合物与具有AGTATTGCAGACATAGTCGT的3'端引导RNA和ACTGCCCGACTCAATAACTT的5'端引导RNA结合,目标是关键外显子的5'和3'端。这导致了一个742bp的染色体11的缺失(位置120485061到120485802),插入了ATAG。(GRCm38参考)(J:237616)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NCrl
Endonuclease-mediated
基因内删除
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1
1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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