这个等位基因来自TCPR0420项目,由位于表观基因组学中心的实验产生,通过向细胞注入Cas9 mRNA和四种引导RNA(含spacer序列ATAATTCCGTCTCACCTATG、ATTCCCTCCAGAGCTGACCT、CTAAATAGATGGATAAGCTC和CGCATGGCGGCCTCGCAGAA)来实现。这导致了16号染色体(Chr19)上一个601bp的缺失,起始位置在38,069,489,结束于38,070,089(GRCm38参考构建)。(来源:J:237616)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NCrl
Endonuclease-mediated
基因内删除
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1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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