这个来自TCPR0880项目的等位基因是在表型基因组学中心通过电穿孔,使用GATACATTGGAGAGGTGAAG和GCCAGGCATAATGAAATACA的单引物RNA与Cas9核酶复合物一起产生的,目标是ENSMUSE00000680067和ENSMUSE00000680066基因的5'端,以及TAAAATGGAACCTGCCACGT和CTGCCAACTATTCACTTAAA针对3'端。这导致了chr13:100092104至100094183区段的2,080bp缺失,以及12bp的插入,插入内容为TAGGAATAAATC(GRCm38建库)。(J:237616)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NCrl
Endonuclease-mediated
基因内删除
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1
2
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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