在exon 4的上游插入了一个FRT-flanked诺卡因抗性基因座。exon 5经过一个核苷酸替换(AGC变为GAC),导致第120位的氨基酸由丝氨酸(Ser)变为天冬氨酸(Asp,S120D)。这个改变制造了一个磷酸类似物版本。通过Flp介导的重组移除了选择性基因座。(来源:J:260973)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6NTac x 129S6/SvEvTac)F1
Targeted
Insertion, Nucleotide substitutions
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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