Exon 2被LoxP位点前后标记,随后在第二个LoxP位点后插入了一个FRT-介导的PGK-neomycin筛选元件。通过Flp介导的重组,这个筛选元件被去除了。Cre介导的重组移除了Exon 2,导致了框移突变,产生了一个提前终止的转录本,只编码前14个氨基酸。(来源:J:241850)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
插入,基因内删除
--
1
9
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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