L1L2_Bact_P cassette,包含FRT-En2剪接接受器(SA)-IRES-lacZ-SV40poly(A)信号(pA)-loxP人类β-actin启动子-neoR-SV40poly(A)信号(pA)-FRT-loxP序列,被插入到exon 3上游,且在exon 3下游额外增加了一个loxP位点(位置152817361)。通过Cre介导的重组,去除了含floxed neo的元件和exon 3。在同源纯合子的粒细胞匀浆中, Western blot分析未检测到基因产物(蛋白质)。(来源:J:260777)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count