CRISPR/Cas9技术被用来在exon 3的UBR域中,将 cysteine 121 替换为一个早停密码子,从而导致蛋白质缺失。 Western blot分析证实了P16睾丸中没有蛋白表达(来源:J:243410)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x CBA)F2
Endonuclease-mediated
核苷酸替换
--
1
1
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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