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中文
靶向载体被设计成插入一个位于内皮1的loxP序列附带STOP片段的区域。第4外显子被修改，将第146位的Alanine替换为Threonine（p.A146T），这是一种在胃肠道和血液癌症患者中常见突变。内皮4还插入了一个FRT引导的Neomycin抗性基因元件，随后通过Flp介导的重组移除了neo cassette。（来源：J:276349）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
