由Cre介导的loxP位点重组,删除了位于第六外显子的序列,导致了PER2蛋白的缺失。这个缺失产生了一个含有188个N端氨基酸(总共1257个)的片段,后面跟着23个不相关的、不含与其它时钟蛋白交互结构域的氨基酸。(来源:J:236282)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
基因内删除
--
1
2
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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