这个靶向向量来自威康信托桑格研究所的KOMP(敲除小鼠项目),用于在X染色体的9455699位点(GRCm38构建)上游插入一个包含FRT-lacZ-loxP-neo-FRT-loxP的L1L2_Bact_P序列,而在5号外显子下游则有一个loxP位点(位置9454892)。通过Flp介导的重组,FRT标记的lacZ/neo片段被移除了。(来源:J:245699)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NTac
Targeted
插入
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1
3
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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