Tg(ALB-PCSK9)APfzr

The transgenic construct contains a composite human albumin (ALB) promoter, containing a 235 bp SV40 enhancer element and a 213 bp albumin promoter element, directing expression of human proprotein convertase subtilisin/kexin type 9 (PCSK9) cDNA, followed by a C-terminal V5 tag. A chimeric intron (from pRL-SV40) was inserted between the promoter and PCSK9 cDNA to enhance expression. The transgene expresses primarily in the kidney. (J:158079)