Adamts16^em1(IMPC)H

This allele from IMPC was generated at Medical Research Council Harwell by injecting CAS9 RNA and 4 guide sequences which resulted in a 923nt deletion. The allele results in a complete loss of exon 5, which encodes part of the highly conserved, zinc-dependent metalloprotease domain; splicing from exon 4 to exon 6 results in a predicted frame-shift and early chain termination due to a premature stop codon. (J:237616, J:283272)