在8周龄的同源性小鼠中,通过插入疑似来源于Thg1l和Gm2420的编码序列,创造出了一个框架移位突变。RT-PCR和 Western blot 的结果显示,这些小鼠睾丸中表达缺失。(来源:J:251285)
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A frameshift mutation was created by the insertion of coding sequence suspected to derive from Thg1l and Gm2420. RT-PCR and western blot analyses confirmed the absence of expression in testes from homozygous mice at 8 weeks of age. (J:251285)