Tg(CRY2*A260T)25Ljp

The transgenic construct contains human BAC RP11-1084E2, encoding full-length CRY2 and incorporating an A260T (amino acid)/GAACGCCA to GAACACCA (nucleotide) mutation. Founder line 25 carries 10 copies of the transgene. The A260T missense mutation was identified in one family affected with Familial Advanced Sleep Phase (FASP). The mutation is located in the phosphate loop of the flavin adenine dinucleotide (FAD) binding domain. (J:257412)