Cre重组酶、合成的内含子、木鼠肝病毒的后转录调控元件(WPRE)、牛生长激素polyA(bGH pA)以及FRT引导的PGK-neomycin cassette被用来替换小鼠Tenm3基因在exon 1中3'端的起始转录子序列,通过胚胎干细胞的同源重组。neomycin cassette保留了下来,这个突变起到了Tenm3无蛋白表达的null等位基因作用。(来源:J:257337)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129S6/SvEvTac)F1
Targeted
插入,基因内删除
--
1
2
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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