CRISPR/Cas9介导的重组去除了LRR9域的21个氨基酸残基,但保留了基因的开放阅读框。 Western blot结果显示,该基因的整体表达没有改变。免疫沉淀分析证实了这种突变导致对Nlgn2的结合被干扰。(来源:256117)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6J
Endonuclease-mediated
基因内删除
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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