在该构建中,通过普遍的CMV即时早期增强子和鸡β-actin启动子控制,包含了小鼠Il11的cDNA,同时在启动子和cDNA之间插入了loxP标记的终止子。通过Cre重组酶,可以实现条件性过表达,因为Cre会剔除终止子(来源:J:250268)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6N
Targeted
插入
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5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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