CreERT2-pA-FRT-Neo-FRT被插入到Trp63基因的第4外显子,导致Trp63蛋白isoform在第115位氨基酸后形成一个框内融合。雄性嵌合体小鼠与雌性FLPeR小鼠杂交,以去除Frt-flanked的PGK-neo cassette。(来源:J:249188)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入
--
1
16
11

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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