包含3-10号外显子的基因区域被替换为一个包含2-10号外显子的Ptgs2基因片段,后面跟着一个敲除neo cassette的floxed系统。通过Cre介导的重组,neo cassette被去除了。qPCR结果显示,多种组织中检测到了融合的Ptgs1-Ptgs2转录本的表达。(来源:J:256419)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Targeted
未定义
--
1
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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