Cas9和引导序列GTACATCTCTGTCGGCTATG针对H2-D1b,ATAATCCGAGATTTGAGCCG针对H2-K1d,被注入到NOD/ShiLtDvs胚胎中,导致了二个exon 2的缺失,一个11bp,另一个3bp,以及单个碱基的H2-K1em1Dvs变异。(来源:J:257229)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count