Exon 4编码的双特异性磷酸酶域(DSPD)被通过同源重组替换为诺卡因抗性基因。基因表达缺失通过Northern blot和脑及肝脏组织中使用DSPD外显子和前3个上游外显子的探针,从纯合突变动物中进行了验证。Cre介导的重组去除了选择性载体。(来源:199271)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
5
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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