Exon 7被替换成经过修改的7到11号外显子,去除了248到337位氨基酸,后面跟着Flag-HA标签、转录终止、FRT引导的诺卡因抗性基因座,接着是一个LoxP位点。通过Flpe介导的重组移除了诺卡因基因座。两个胶原重复区域都被删除了。(来源:J:249238)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count