4-5号外显子由loxP位点包被,上游插入了一个FRT-介导的诺卡因抗性基因座。通过Flpe介导的重组移除了诺卡因基因座。随后,Cre介导的重组导致了4和5号外显子的同框缺失,去除了两个EGF区域。测序结果显示从3号外显子到6号外显子的正确拼接(来源:J:249238)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
插入,基因内删除
--
1
2
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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