Fabp4基因的启动子驱动表达的人源性caspase 8融合蛋白,该蛋白由串联的FKBPv(phe36val突变FKBP)二聚体区域驱动。融合蛋白中包含一个myristoylation位点,用于细胞膜附着。在Fabp4特异性脂肪细胞驱动下,当FKBP区域诱导二聚化时,会引发脂肪细胞的广泛凋亡。只产生了单一的克隆。(来源:J:99639)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
FVB
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1
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13

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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