The targeting vector contains a loxP site flanked PGK-neo cassette, a mutant mouse Yap1 gene (with an amino acid substitution of serine-to-alanine at position 112), viral 2A peptide sequence, HIST1H2BJ/GFP (H2B-GFP) cDNA, beta-globin and polyadenylation sequence, under the control of the tetO, tetracycline-responsive regulatory element (TRE-tight). (J:255620)