将一个含Neomycin选择基因的IRES-Cre cassette插入Dlx2基因的3'非翻译区,通过Frt座点进行标记。在ES细胞中实现靶向整合,产生转基因克隆。阳性后代与一个Flp剔除线杂交,以去除Neomycin抗性基因。(来源:J:255053)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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