将一个含Neomycin选择基因的IRES-Cre cassette插入Dlx2基因的3'非翻译区,通过Frt座点进行标记。在ES细胞中实现靶向整合,产生转基因克隆。阳性后代与一个Flp剔除线杂交,以去除Neomycin抗性基因。(来源:J:255053)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count