一个名为Velocigene的ZEN-Ub1基因片段替换了染色体7(Genome Build37)上16081bp大小的基因区域,位置在134072572-134088652。通过Cre介导的重组,hUBCpro-neo-p(A) cassette被移除。 Western blot结果显示,纯合突变小鼠的各脑区域(如海马、皮质、小脑和中脑)中蛋白质表达完全丢失,而杂合子的表达则减少了大约50%(来源:J:250125)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NTac
Targeted
插入,基因内删除
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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