Phox2a^{tm1(Asci2*)Jbr}

A cDNA for rat Asic2 harboring a G430F mutation was inserted between the first and second exon of the gene, preceded by a floxed EGFP-Neo-STOP-IRES cassette, itself preceded by a splice acceptor site. Upon Cre-mediated recombination the mutant rat Asic2, encoding a toxic allele of the sodium channel, is transcribed from the endogenous promoter. (J:249229)