通过Cre介导的loxP位点重组,包括5' UTR的一部分和编码蛋白质N端280个氨基酸的2542个氨基酸的exon2被移除,这发生在生殖细胞中。通过在纯合突变小鼠的蛋白质提取物中进行 Western blot 分析,证实了编码蛋白的表达被抑制。(来源:J:251454)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
基因内删除
--
1
3
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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