靶向载体设计用于将exon 2替换为一个由loxP位点介导的诺卡因抗性(neo)基因座。通过将Cre重组酶表达载体短暂转染到ES细胞中,删除了neo基因座。由此产生的GATAs蛋白被截短了。(来源:J:257058)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1b-m2
Targeted
基因间区删除
--
1
14
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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