Tg(TLR4*D299G)4Haj

The transgene was generated with a modified version of human genomic BAC RP11-150L1. Using recombineering, an A>G substitution was introduced that resulted in a D299G (p.Asp299Gly) mutation in the translated petide. The copy number of this allele, as determined by RT-PCR, is 4. (J:248428)