在宿主基因座中插入了以下组件:CAG启动子、loxP序列夹杂的STOP cassette、转录起始点、FLAG和Myc的抗原标签序列、小鼠孕酮受体基因Pgr的A亚型cDNA,以及poly(A)特征。这构建了一个条件性可诱导突变体,只有在通过Cre介导的重组移除STOP cassette后,插入基因才会表达。(来源:J:243133)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129S7/SvEvBrd-Hprt1b-m2
Targeted
插入
--
--
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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