设计了一个靶向载体,它包含一个CreERT2融合基因(一种Cre重组酶与人雌激素受体配体结合区域连接),后面跟着一个由FRT标记的诺卡因抗性基因(neo)片段,这个片段位于MAS相关G蛋白偶联受体D(Mrgprd)基因起始密码子下游。通过与B6.129S4-Gt(ROSA)26Sor/J(库存号007844)小鼠杂交,去除了neo cassette。(来源:J:245897)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
插入
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1
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13

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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