这段基因的第2外显子和第2内含子(从起始翻译点至外显子末尾共153bp,加上内含子开头的130bp)被替换为含有小鼠核定位信号(NLS)的lacZ报告基因,周围是loxP序列标记的抗氨苄青霉素基因座。随后通过Cre介导的重组移除了neo cassette(来源:J:242792)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入,基因内删除
--
1
6
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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