七重复的四环素响应元件(tetO)序列能驱动人类基因中插入AYVM的同框表达,该插入发生在M774位点(使用YVMA是因为M774insAYVM和A775insYVMA导致相同的氨基酸变化)。建立了两个突变体:26(拷贝数低,表达水平高)和5B(拷贝数高,表达水平低)。(来源:J:143874)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
FVB/N
--
插入
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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