在exon 2的上游插入了loxP位点,通过同源重组在exon 4下游插入了loxP位点和FRT标记的neo cassette。随后通过Flp介导的重组移除了neo cassette。(来源:J:229464, J:243753)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count