靶向载体设计用于在基因的第六外显子上游插入一个loxP位点,随后是带有FRT标签的诺卡因抗性(neo)基因座,接着在第六外显子下游插入另一个loxP位点。通过Flp介导的重组,FRT标记的neo基因座被移除,导致第六外显子被标记为可剪接。(来源:J:341591)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129S6/SvEvTac x C57BL/6NCrl)F1
Targeted
插入
--
1
6
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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