靶向载体设计用于在基因的第六外显子上游插入一个loxP位点,随后是带有FRT标签的诺卡因抗性(neo)基因座,接着在第六外显子下游插入另一个loxP位点。通过Flp介导的重组,FRT标记的neo基因座被移除,导致第六外显子被标记为可剪接。(来源:J:341591)
Basic Information
(129S6/SvEvTac x C57BL/6NCrl)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count