在exon 3上游插入了一个floxed neo cassette,然后在exon 4下游插入了一个loxP位点。通过Cre介导的重组,去除了neo cassette,使得exons 3和4被留下了去除了内含子的标记。(来源:J:172679, J:228956)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count