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中文
这个构建包含人类β-actin启动子后面跟着一个携带有工程化C>G替换，将arginine的213和215位点替换为alanine的Wlds突变cDNA（p.Arg213Ala, p.Arg215Ala）。这个构建被注入到不表达Wlds的C57BL/6 x CBA杂交胚胎的卵母细胞核中。这两个突变削弱或消除了核定位信号，导致翻译出的肽类更倾向于细胞质分布，尽管有一小部分仍会定向到细胞核。（来源：J:144846）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
