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中文
这段基因编码压缩区域的部分，即蛋白质活性域之一，被替换为合成序列，其中13个lysine和arginine的密码子被替换为alanine。这是通过CRISPR/Cas9内切酶辅助同源重组实现的，方法是将转录基因载体、两个sgRNA和Cas9 mRNA注射到C57BL/6的受精卵中。这个等位基因编码的蛋白质活性降低了。(来源：J:242063)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
