使用重组修复技术,CreTM-FrtNeoFrt载体被插入到了Dclk1基因在小鼠BAC克隆RP23-283D6中第二外显子起始的ATG密码子上游。修改后的BAC构建被注入了CBA x C57BL/6J的受精卵中。获得了4个转基因阳性的杂交品系,然后与C57BL/6J小鼠进行了回交。当未指定特定品系或多个品系合并时,使用#符号表示。来源:(J:209426)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(CBA x C57BL/6J)F1
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10

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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