将含有改良cre重组酶(带有polyA信号序列)的cDNA插入到小鼠Stab2基因的第1外显子中,通过BAC克隆,使得cre表达由BAC基因的调控序列驱动。由此得到的改造BAC被用来构建这个转基因。识别出三个杂交系,1.1、1.2和1.3。实验中使用了在肝窦内皮细胞中显示cre活性的1.2线。(来源:J:243226)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6NCrl
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插入
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3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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