The transgenic construct contains sequence encoding a four-repeat domain of human MAPT protein (TauRD, Q244-E372) under the control of the mouse Prnp gene promoter and the tetO, tetracycline-responsive regulatory element (from the moPrP-tetP vector, 42-bp tet operator sequence copies followed by the constitutively active, minimal human cytomegalovirus promoter). (J:240784)