这个转基因构建包含了编码小鼠Selp外分泌域全长的cDNA,连接一个由Ca2+依赖性mAb HPC4识别的C端8个氨基酸表位,所有这些都受到鼠Alb(白蛋白)基因启动子的控制,并以牛生长激素的3'poly(A)信号序列结尾。建立的祖先小鼠稳定表达的蛋白质在血浆中的量大约比正常高3.5倍。(来源:J:243484)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6
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1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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