Tamoxifen诱导的Cre重组酶(MerCreMer:连接在两端经过改造的雌激素受体配体结合域的Cre重组酶)的cDNA被通过同源重组插入到exon 1的起始ATG位置。质粒中还包含了溶原性白喉毒素A的cDNA和一个FRT标记的诺卡因选择座,用于负向和正向筛选。通过Flp介导的重组,FRT标记的诺卡因座被移除。(来源:J:241168)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入
--
1
--
18

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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