A construct containing a slice acceptor site, floxed-neo-stop cassette, HA-tagged human CARD11 cDNA with an isoleucine codon after the leucine codon at position 225 (L225LI), IRES-eGFP cassette and polyA sequence was inserted in intron 1. The human cDNA was derived from a diffuse large B-cell lymphoma and carries a constitutively active mutation. (J:228288)